diff --git a/cmake/presets/most.cmake b/cmake/presets/most.cmake
index eb26b38928..27ce57621c 100644
--- a/cmake/presets/most.cmake
+++ b/cmake/presets/most.cmake
@@ -48,7 +48,6 @@ set(ALL_PACKAGES
   PHONON
   PLUGIN
   POEMS
-  PYTHON
   QEQ
   REACTION
   REAXFF