diff --git a/cmake/Modules/Packages/MESSAGE.cmake b/cmake/Modules/Packages/MESSAGE.cmake
index 3c1bdde855..aff9c2964a 100644
--- a/cmake/Modules/Packages/MESSAGE.cmake
+++ b/cmake/Modules/Packages/MESSAGE.cmake
@@ -1,4 +1,7 @@
 if(PKG_MESSAGE)
+  if(LAMMPS_SIZES STREQUAL BIGBIG)
+    message(FATAL_ERROR "The MESSAGE Package is not compatible with -DLAMMPS_BIGBIG")
+  endif()
   option(MESSAGE_ZMQ "Use ZeroMQ in MESSAGE package" OFF)
   file(GLOB_RECURSE cslib_SOURCES ${LAMMPS_LIB_SOURCE_DIR}/message/cslib/[^.]*.F
       ${LAMMPS_LIB_SOURCE_DIR}/message/cslib/[^.]*.c
diff --git a/lib/message/cslib/src/cslib.h b/lib/message/cslib/src/cslib.h
index b4da968026..f2bf006881 100644
--- a/lib/message/cslib/src/cslib.h
+++ b/lib/message/cslib/src/cslib.h
@@ -17,6 +17,10 @@
 
 #include <stdint.h>
 
+#if defined(LAMMPS_BIGBIG)
+#error CSlib is not compatible with -DLAMMPS_BIGBIG
+#endif
+
 namespace CSLIB_NS {
 
 class CSlib {